One of the most outstanding projects supported by the Hans and Ilse Breuer Foundation with a grant amounting to Euro 280,000, was the acquisition of a powerful confocal laser microscope for the renowned Adolf Butenandt Institute in München.
With the help of ultra modern and highly sensitive microscopes, employees at the Research Institute can now achieve far-reaching advances in basic research of Alzheimer’s disease.
"With the help of modern microscopic techniques, we can now study the path of individual molecules through cells. The confocal microscope enables a variety of investigative methods where for example cells can be dissected in different optical planes. With the help of this technique, we have recently succeeded for example to find where within the cell the Alzheimer claws are jointed and where they can snap" - Professor Doctor of Science Christian Haass
In another project sponsored by the Hans and Ilse Breuer Foundation, the causes for Alzheimer’s disease are explored through biochemical and molecular biological methods. The contribution made by the Foundation enabled the establishment by Berliner researcher Prof. Gerd Multhaup of a sponsored research unit which works in an interdisciplinary fashion and which provides structure and function analysis (techniques of surface plasmon resonance – in short SPR – and mass spectrometry). The aim is to analyse the protein complexes responsible for the disease and to thus find a way which can prevent, delay or cure the disease.
Initial successes are documented through publications which have appeared in journals such as the Journal of Biological Chemistry or EMBO.